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- Increases Egg Quality, Ideal for PCOS patients.
- Normalises Insulin Levels in patients who are insulin resistant.
- Normalises low estrogen levels within 8 days after 1st sachet
- Promotes Healthy Eggs.
- Corrects High Free Testosterone Levels
- Myo-Inositol is a key ingredient found in the folicular fluid of healthy eggs.
- Patients who have been diagnosed with PCOS or older patiens often lack myo-inositol and therefore create lower quality eggs, thereby diminishing the chances of a successful pregnancy.
- It normalises the metabolic, hormonal and folicular processes in the body. PCOS patients often have difficulty losing weight as a result of being insulin resistant. Inofolic will help with this too.
The following hormones play an important role in the cycle of a woman,
- Follicle Stimulation hormone (FSH)
- Luteinizing hormone (LH)
In order for a woman to fall pregnant, it is important that the female hormones are in balance. If one of the female hormones are imbalanced, the function or production of other hormones may be compromised.
It is also important to note that other hormones, for example insulin that is a metabolic hormone, may also influence the production of female hormones.
The production of female hormones works in a cycle and if any of the hormones is not produced or not regulated in sequence, the cycle is broken or disappears.
The production of estradiol in the ovaries is critical for the regulation and release of:
- Follicle Stimulating Hormone (FSH) – remember FSH is responsible for the recruitment and development of follicles (bag in which eggs develop) and the oocytes (eggs).
- Luteinizing hormone (LH) that is responsible for the release of a dominant egg during ovulation.
Without the regulation of estrogen, the brain will increase FSH and LH levels. An increase in the FSH levels will result in a number of follicles to develop but no egg may be released because the LH levels is higher than normal but does not peak to cause ovulation.
Woman is born with a fixed number of follicles (± 400 thousand). Several follicles will grow per month but normally only one dominant follicle will release its egg (ovulation).
After ovulation, the follicle that releases the egg will become a corpus luteum that produces progesterone to prepare the uterus for implantation (thickening of the endometrium) of the embryo. If ovulation does not take place, progesterone levels may not increase and there may be no menstruation phase because the endometrium did not develop.
The quality of all the follicles is not the same and several factors may have an influence on the normal development of the follicle and egg. Normally the best quality follicles will be used during the early reproductive stage and as the women gets older (above 35) , the number of follicles, and the quality of the follicles will decrease until none follicles are left (menopause).
Due to the imbalance of female hormones woman may struggle with an increase in the production of male hormaones which may result in acne, hursitism (unnatural hair development on females body) and/or Alopesia (loss of female body hair). The Ferriman-Gallwey hursitism score may be used to establish the excess of male hormones in female.
1. When can you start to take Inofolic?
There is no set time. Treatment should begin as soon as possible in order to achieve the desired results.
2. For how long can Inofolic be administered?
Most of the clinical data indicate that at 6 months of treatment the effects of the product are visible. Everything depends on the therapeutic target. If the main objective is to treat hyperandrogenism, clinical results are visible after 3 months and become more significant at 6 months.
The endocrine-gynecological disorders related to the PCO may require chronic treatment.
3. How to take Inofolic
The majority of the clinical trial are based on the administration of 4 g of myo-inosito, which correspond to 2 sachets of Inositol per day .
4. Inofolic: how does it taste?
It has a sweet taste.
5. May the long-term administration of Inofolic give any problem?
Inofolic contains two compounds already present in the body, so the long-term supplementation does not induce side effects but allows to restore the physiological levels.
6. Are there any contraindications?
There is no contraindication to the use of Inofolic. Supplementation with Inofolic provides two nutrients useful to compensate the deficits of these nutrients (Baillargeon, 2006, Maria de la Calle, 2007). Therefore, the co-administration with other drugs is perfectly possible.
We recommend that the association with the contraceptive pill in order to reduce the cardiovascular risk resulting from the use of oral contraceptives in the long term (Minozzi et al., 2011).
7. Can it be admistered during pregnancy?
Clinical trials conducted on pregnant women showed that myo-inositol reduces the risk of gestational diabetes in women at high risk (D'Anna et al. 2011). The intake of myo-inositol in the periconceptional period reduces the folic acid-resistant neural tube defects (Cavalli, 2011).
8. What is the role of folic acid in Inofolic?
The administration of folic acid during the periconezional periodat the recommended daily dose of 400μg. The folic acid prevents the 70% of NTDs.
In women with polycystic ovary syndrome low folate levels are related to high levels of homocysteine. Knowing that women with PCOS have higher cardiovascular risk than other women, it is important to ensure adequate folic acid supplementation to reduce the levels of homocysteine and thus reducing cardiovascular risk (Maria de la Calle, 2007)
9. Inositol, myo-inositol, D-chiro-inositol? What is the difference?
Inositol has 9 isomers including myo-inositol and D-chiro-inositol. Although both mediate are insulin mimetic, the myo-inositol plays a key role inthe follicular development and it is a markerof good oocytes quality. The D-chiro-inositol mainly plays a role in the regulation of glucose metabolism. Although early studies were performed using the D-chiroinositolo, current data show that the missing isoform in ovary is the myo-inositol which is the only one capable of ensuring the restoration of ovulatory capacity.
10. What is the origin of inositol?
It is of vegetable origin. Inofolic does not contain gluten, lactose or allergen.
11. How does the myo-inositol work in the body?
It works in two ways essentially:
- By improving insulin sensitivity. It 's been shown that insulin resistance has a very important role in PCOS and at the same time that the PCOS patients have a deficiency of myo-inositol (lower plasma levels of myo-inositol, increased urinary excretion). This lack of myo-inositol would be responsible for insulin resistance and compensatory hyperinsulinemia.
Women who received integration of myo-inositol showed improvement in insulin sensitivity, decreased insulin resistance and hyperinsulinemia. Additionally, an improvement of symptoms and signs characteristic of polycystic ovary syndrome was observed.
- By improving the oocytes quality. The Myo-inositol is an important component of the follicle. It has been observed that high levels of myo-inositol in follicular fluid are an indication of good quality oocytes. In vitro, it has been shown that the addition of myo-inositol to the culture medium of murine oocytes improves the meiotic progression and maturation of the oocytes (Chiu et al, 2003).
12. Can inositol improve the oocyte quality in women without polycystic ovary syndrome?
Inofilc improves the oocytes quality independently from the presence of PCO.
13. What associations can be made with Inofolic?
Inofolic can be considered as first line approach evenr associated with oral contraceptives, clomiphene and gonadotropins. Depending on medical advice, Inofolic may be associated with metformin which beside reducing insulin resistance and hyperandrogenism, normalizes the ovarian function and the oocyte maturation
14. What criteria were used to select patients in the trials with Inofolic ?
At least 2 of 3 criteria established in Rotterdam for the diagnosis of PCO oligo / anovulation, hyperandrogenism, polycystic ovaries.
15. What happens when patients do not have insulin resistance?
Since the presence of PCOS has been considered as an inclusion criteria in the clinical studies, whether or not RI was present, everything leads to believe that the product is equally effective in women with polycystic ovary syndrome and without RI. Do not forget that the signaling pathway of phosphatidylinositol-3-P is used by insulin as well as other hormones. For example, the GnRH produced by the hypothalamus, uses this same mechanism to act at the pituitary level. So you can have an effect on the hypothalamic-pituitary-gonadal axis, which leads to normalization of LH / FSH ratio.
Additionally, the effect of myo-inositol on the maturation of the oocytes is independent of insulin resistance and the polycystic ovary syndrome
16. What is the difference with metformin?
The most important difference is the absence of side effects, in particular the gastrointestinal effects which occur with the administration of metformin.
The metformin acts through three mechanisms:
- Reduction of hepatic glucose production.
- Increased sensitivity to insulin
- Slow down the intestinal absorption of glucose.
Inofolic provides inositol, which improves insulin signaling and is a natural component of follicular fluid involved in oocyte maturation, and folic acid which is important in the prevention of NTDs among women seeking pregnancy and helps to reduce elevated homocysteine levels that are typically elevated in women with PCOS.
Raffone et al in 2010 performed a comparative study with 120 patients with PCOS. The group treated with Inofolic did not show any adverse effects compared to the group treated with metformin. Futhermore, the number of pregnancies was higher in the group INOFOLIC (29 vs. 22).